1. ⦁ Traditional Medicine Has a Long History of Contributing to Conventional Medicine and Continues to Hold Promise. (2023, August 10). World Health Organisation. Retrieved from: https://www.who.int/news-room/feature-stories/detail/traditional-medicine-has-a-long-history-of-contributing-to-conventional-medicine-and-continues-to-hold-promise
  2. ⦁ Shubrook, N. (2023, August 22). Top 5 health benefits of mushrooms. BBC Good Food. Retrieved from: https://www.bbcgoodfood.com/howto/guide/health-benefits-mushrooms
  3. ⦁ Fatima, S., Rasool, A., Sajjad, N., Bhat, E, A., Hanafiah, M, M., Mahboob, M. (2019). Analysis and Evaluation of Penicillin Production by Using Soil Fungi. Biocatalysis and Agricultural Biotechnology, 21. https://doi.org/10.1016/j.bcab.2019.101330
  4. ⦁ McHale, E. (2020, June 30). Secret Fungi in Everyday Life. Royal Botanic Kew Gardens. Retrieved from: ⦁ https://www.kew.org/read-and-watch/everyday-fungi-food-medicine#:~:text=Like%20many%20other%20antibiotics%20produced,organ%20transplantation%20and%20cosmetic%20surgery
  5. ⦁ Global Mushroom Coffee Market Forecast to 2030: Rising Awareness of the Medicinal Benefits of Mushrooms Drives Growth. (2023, June 20). Yahoo Finance. Retrieved from: https://finance.yahoo.com/news/global-mushroom-coffee-market-forecast-134300104.html
  6. ⦁ Guide to Lion’s Mane Mushroom. (2023, August 17). Holland and Barrett. Retrieved from: https://www.hollandandbarrett.com/the-health-hub/food-drink/nutrition/guide-to-lion-s-mane-mushrooms-/
  7. ⦁ Perez, A. (2023, June 29). Nine Health Benefits of Lion’s Mane Mushroom: Plus Side Effects. Retrieved from: ⦁ https://www.healthline.com/nutrition/lions-mane-mushroom#depression-and-anxiety
  8. ⦁ Docherty, S., Doughty, F. L., & Smith, E. F. (2023). The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients, 15(22), 4842. https://doi.org/10.3390/nu15224842
  9. ⦁ Mori, K., Obara, Y., Moriya, T., Inatomi, S., & Nakahata, N. (2011). Effects of Hericium Erinaceus on Amyloid β (25-35) Peptide-induced Learning and Memory Deficits in Mice. Biomedical Research (Tokyo, Japan), 32(1), 67–72. https://doi.org/10.2220/biomedres.32.67
  10. ⦁ Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orrù, G., Botta, L., Girometta, C., Guglielminetti, M. L., Savino, E., & Rossi, P. (2017). Dietary Supplementation of Hericium Erinaceus: Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evidence-based Complementary and Alternative Medicine: eCAM, 2017, 3864340. https://doi.org/10.1155/2017/3864340
  11. ⦁ Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2008). Improving Effects of the Mushroom Yamabushitake (Hericium Erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial. Phytotherapy Research, 23(3), 367-372. https://doi.org/10.1002/ptr.2634
  12. ⦁ Mental Health Facts and Statistics. (2020). Retrieved from: ⦁ https://www.mind.org.uk/information-support/types-of-mental-health-problems/statistics-and-facts-about-mental-health/how-common-are-mental-health-problems/#HowCommonAreMentalHealthProblems
  13. ⦁ Chiu, C. H., Chyau, C. C., Chen, C. C., Lee, L. Y., Chen, W. P., Liu, J. L., Lin, W. H., & Mong, M. C. (2018). Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice. International journal of Molecular Sciences, 19(2), 341. https://doi.org/10.3390/ijms19020341
  14. ⦁ Lovering, N. (2024, January 5). Health Benefits of Lion’s Mane. Retrieved from: https://www.forbes.com/health/supplements/health-benefits-of-lions-mane/
  15. ⦁ Yao, W., Zhang, J. C., Dong, C., Zhuang, C., Hirota, S., Inanaga, K., & Hashimoto, K. (2015). Effects of Amycenone on Serum Levels of Tumor Necrosis Factor-α, Interleukin-10, and Depression-like Behavior in Mice After Lipopolysaccharide Administration. Pharmacology, Biochemistry, and Behaviour, 136, 7–12. https://doi.org/10.1016/j.pbb.2015.06.012
  16. ⦁ Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010). Reduction of Depression and Anxiety by Four Weeks Hericium Erinaceus Intake. Biomedical Research, 31(4), 231-237. https://doi.org/10.2220/biomedres.31.231
  17. ⦁ Li, I. C., Chang, H. H., Lin, C. H., Chen, W. P., Lu, T. H., Lee, L. Y., Chen, Y. W., Chen, Y. P., Chen, C. C., & Lin, D. P. (2020). Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium Erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Frontiers in Aging Neuroscience, 12, 155. https://doi.org/10.3389/fnagi.2020.00155
  18. ⦁ Li, I. C., Lee, L. Y., Tzeng, T. T., Chen, W. P., Chen, Y. P., Shiao, Y. J., & Chen, C. C. (2018). Neurohealth Properties of Hericium Erinaceus Mycelia Enriched with Erinacines. Behavioural Neurology, 2018, 5802634. https://doi.org/10.1155/2018/5802634
  19. ⦁ Leonard, J. (2018, October 18). What Are the Benefits of Lion’s Mane Mushroom? Retrieved from: https://www.medicalnewstoday.com/articles/323400
  20. ⦁ Martínez-Mármol, R., Chai, Y., Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S., Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin Derivatives Activates a Pan-neurotrophic Pathway in Central Hippocampal Neurons Converging to ERK1/2 Signaling Enhancing Spatial Memory. Journal of Neurochemistry, 165, 791–808. https://doi.org/10.1111/jnc.15767
  21. ⦁ Buntajova, D. (2023, February 13). The Mushroom That Could Protect You from Alzheimer’s Disease – ‘Significant Impact’. The Express. Retrieved from: https://www.express.co.uk/life-style/health/1734093/dementia-alzheimers-disease-diet-lions-mane-mushroom-lower-risk/amp
  22. ⦁ Lai, P. L., Naidu, M., Sabaratnam, V., Wong, K. H., David, R. P., Kuppusamy, U. R., Abdullah, N., & Malek, S. N. (2013). Neurotrophic Properties of The Lion’s Mane Medicinal Mushroom, Hericium Erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554. https://doi.org/10.1615/intjmedmushr.v15.i6.30
  23. ⦁ Kolotushkina, E. V., Moldavan, M. G., Voronin, K. Y., & Skibo, G. G. (2003). The Influence of Hericium Erinaceus Extract on Myelination Process in Vitro. Fiziolohichnyi Zhurnal (Kiev, Ukraine), 49(1), 38–45. https://europepmc.org/article/med/12675022
  24. ⦁ Tsai-Teng, T., Chin-Chu, C., Li-Ya, L., Wan-Ping, C., Chung-Kuang, L., Chien-Chang, S., Chi-Ying, H. F., Chien-Chih, C., & Shiao, Y. J. (2016). Erinacine A-enriched Hericium Erinaceus Mycelium Ameliorates Alzheimer’s Disease-related Pathologies in APPswe/PS1dE9 Transgenic Mice. Journal of Biomedical Science, 23(1), 49. https://doi.org/10.1186/s12929-016-0266-z
  25. ⦁ Abdullah, N., Ismail, S, M., Aminudin, N., Shuib, A, S., Lau, B, F. (2011). Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine, Vol 2012. https://doi.org/10.1155/2012/464238
  26. ⦁ Diling, C., Chaoqun, Z., Jian, Y., Jian, L., Jiyan, S., Yizhen, X., & Guoxiao, L. (2017). Immunomodulatory Activities of a Fungal Protein Extracted from Hericium Erinaceus Through Regulating the Gut Microbiota. Frontiers in Immunology, 8, 666. https://doi.org/10.3389/fimmu.2017.00666
  27. ⦁ Trovato, A., Siracusa, R., Di Paola, R., Scuto, M., Ontario, M. L., Bua, O., Di Mauro, P., Toscano, M. A., Petralia, C. C. T., Maiolino, L., Serra, A., Cuzzocrea, S., & Calabrese, V. (2016). Redox Modulation of Cellular Stress Response and Lipoxin A4 Expression by Hericium Erinaceus in Rat Brain: Relevance to Alzheimer’s Disease Pathogenesis. Immunity & Ageing: I & A, 13, 23. https://doi.org/10.1186/s12979-016-0078-8
  28. ⦁ Liang, B., Guo, Z., Xie, F., & Zhao, A. (2013). Antihyperglycemic and Antihyperlipidemic Activities of Aqueous Extract of Hericium Erinaceus in Experimental Diabetic Rats. BMC Complementary and Alternative Medicine, 13, 253. https://doi.org/10.1186/1472-6882-13-253
  29. ⦁ Lion’s Mane Mushroom. (2016, September 8). Alzheimer’s Drug Discovery Foundation. Retrieved from: https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Lions-Mane-Cognitive-Vitality-For-Researchers.pdf
  30. ⦁ Chen, C. C., Tzeng, T. T., Chen, C. C., Ni, C. L., Lee, L. Y., Chen, W. P., Shiao, Y. J., & Shen, C. C. (2016). Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium Erinaceus. Journal of Natural Products, 79(2), 438–441. https://doi.org/10.1021/acs.jnatprod.5b00474
  31. ⦁ Choi, W. S., Kim, Y. S., Park, B. S., Kim, J. E., & Lee, S. E. (2013). Hypolipidaemic Effect of Hericium Erinaceum Grown in Artemisia Capillaris on Obese Rats. Mycobiology, 41(2), 94–99. https://doi.org/10.5941/MYCO.2013.41.2.94